Carpal Tunnel Syndrome Disease

Published Date : Nov 2023
Category : Neurodegenerative Disorders
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"Unveiling the Knot of Pain: Overcoming Carpal Tunnel Syndrome Challenges"

The compression of the median nerve during its passage through the carpal tunnel results in Carpal Tunnel Syndrome (CTS). It is the high pressure inside the carpal tunnel that is the main cause of CTS.

According to NIH, in the general population, CTS affects 1% to 5% of people. With a 3:1 female-to-male ratio, CTS is more common in females than in males. Obese people have a twofold increased chance of acquiring CTS. CTS usually appears in adults between the ages of 40 and 60, and it is rare in teenagers.

The transverse carpal ligament at its top boundary and the carpal bones at its lower limit form the carpal tunnel, a narrow corridor in the wrist. Nine flexor tendons are housed in the carpal tunnel, which also houses the median nerve. The development of CTS is a result of ischemia damage to the median nerve, high blood pressure, and mechanical stress.

Within the carpal tunnel, the typical pressure ranges from 2 to 10 mmHg. But when the wrist is extended or flexed, the pressure rises eight to ten times higher than usual. Repeated compression of a nerve cause demyelination at the point of compression. A disturbance in blood flow to the endoneurial capillary system results in the development of endoneurial edema.

Patients are more susceptible to carpal tunnel syndrome (CTS) due to a number of factors, yet the precise cause of the ailment is still unknown. Changes in the body's fluid balance, modifications to the carpal tunnel, or the presence of direct neuropathic causes increase the likelihood of developing CTS.

Among the risk factors include carpal subluxation or dislocation. Menopause, obesity, kidney failure, pregnancy, hyperthyroidism, oral contraceptive use, diabetes, congestive heart failure, vitamin poisoning or insufficiency, etc.


Carpal tunnel syndrome typically manifests its symptoms gradually and without a specific injury. For a long time, many individuals experience intermittent symptoms. Nevertheless, symptoms become more frequent or last longer as the illness worsens.

The following are symptoms of carpal tunnel syndrome:

  • Pain, numbness, tingling, and burning, usually in the thumb, index, middle, and ring fingers. People are frequently woken up at night by this.
  • Periodically, the thumb, index, middle, and ring fingers experience shock-like feelings
  • Tingling or pain radiating up the forearm and toward the shoulder
  • Hand clumsiness and weakness, which makes it challenging to execute small motions like buttoning garments
  • Dropping objects because to numbness, weakness, or loss of proprioception.

Diagnostic Analysis

Physical Examination

A physical examination is performed by the provider. A physician examines the patient's strength of hand muscles and sensation in their fingers.

Many patients get symptoms when they bend their wrist, tap on the nerve, or just press on the nerve.

Electrophysiological tests

To assess whether the median nerve is under excessive pressure and to examine how effectively the nerve is functioning, doctors prescribe electrophysiological testing of the nerves.

Carpal tunnel syndrome severity and whether the nerve is squeezed in other places is able to be assessed with these tests.

ECG examinations include-

  • Nerve conduction studies (NCS): These diagnostic procedures quantify the signals that flow through the hand and arm nerves and identify a deficiency in a particular nerve's ability to convey signals. The severity of the issue is assessed and therapy recommendations made with the aid of nerve conduction investigations.
  • Electromyogram (EMG): Measurement of the electrical activity in muscles is done by an electromyogram or EMG. The patient's nerve and muscle damage are indicated by the EMG results.

Imaging Test

  • X-ray: Dense structures like bone are able to seen in images obtained from X-rays. If the patient has wrist pain or limited wrist motion, the doctor orders X-rays to rule out other possible reasons for the symptoms, like arthritis, ligament damage, or fractures.
  • Magnetic resonance imaging (MRI) scans: The body's soft tissues are more clearly observed on magnetic resonance imaging (MRI) scans. An MRI is ordered by a doctor in order to search for anomalous tissues that are possibly affecting the median nerve or to help rule out other possible explanations of the symptoms. A magnetic resonance imaging (MRI) aids in the diagnosis of nerve disorders, including tumors and scarring from trauma.
  • Ultrasound: High-frequency sound waves are used in ultrasounds to assist produce images of tissue and bone. The doctor advises having an ultrasound of the wrist to check for compression of the median nerve.

Diagnostic Market Players

Diagnostic Market Players

Diagnostic Product

General Electric Company (GE Healthcare)



SIGNA™ Pioneer

Siemens Healthineers

SIGNA™ Architect

Med Imaging Solutions

Discovery™ MI

Canon Medical Systems Corporation

VUE Point™ FX

Gastro diagnostic.Ltd


Radiance Imaging system


Fujifilm Holdings Corporation (FUJIFILM Medical Systems)

SmartRelease® ECTR, LLC.,

Smith & Nephew plc.


CONMED Corporation

EPIQ Elite

Integra LifeSciences


microaire surgical instruments


Stryker Corporation


Sonex Health, LLC


Micromed Solutions for Neurophysiology



Treatment Analysis

"Unleashing Relief, Embrace Freedom: The Path to Carpal Tunnel Liberation"

The severity of the condition determines the CTS avenues for treatment. Wrist splinting, medicine, and surgery are available forms of treatment. If the patient's symptoms were mild to severe and had been coming and going for less than ten months, splinting and other conservative measures were more likely to be beneficial.

Non-Surgical Intervention

  • Bracing or Splinting: A brace or splint worn at night prevents the patient's wrist from bending while they sleep. Retuning the wrist to a neutral or straight position eases pressure on the carpal tunnel nerve. Wearing a splint during the day when engaging in activities that exacerbate symptoms is also beneficial.
  • Nerve Gliding Exercises: Exercises designed to increase the median nerve's range of motion within the carpal tunnel are beneficial for certain patients. Exercises that a therapist or doctor has prescribed.


Through the cutting of the ligament pushing on the median nerve, carpal tunnel surgery aims to relieve pressure.

Two alternative procedures could be used to execute the surgery.

  • Endoscopic Surgery: To examine within the carpal tunnel, a surgeon utilizes an endoscope, which is a telescope-like instrument with a tiny camera attached. Through one or two tiny hand or wrist incisions, the surgeon slices the ligament. Rather than using a telescope to guide the instrument used to sever the ligament, some surgeons employ ultrasonography. In the initial days or weeks following surgery, endoscopic surgery causes less pain than open surgery.
  • Open Surgery: The doctor creates a tiny incision in the palm during an open carpal tunnel release procedure to view the inside of the hand and wrist. The transverse carpal ligament—the carpal tunnel's roof—will be divided by the doctor during the treatment. As a result, the tunnel gets bigger and the median nerve is under less pressure.


  • Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs, such Ibuprofen (Advil, Motrin IB, and other brands), assist in short-term carpal tunnel syndrome pain relief. However, there is no proof that these medications alleviate carpal tunnel syndrome.
  • Corticosteroid: A doctor injects a corticosteroid, like cortisone, into the carpal tunnel to ease pain. The doctor occasionally direct these injections with the use of an ultrasound. Corticosteroids reduce edema and inflammation, which releases pressure from the median nerve. For the treatment of carpal tunnel syndrome, injections rather than oral corticosteroids are thought to be more beneficial.

Treatment Market Players

Treatment Market Players

Treatment Products

GlaxoSmithKline plc


Arthrex, Inc


Johnson & Johnson Services


Bayer AG


F. Hoffmann-La Roche Ltd




Pfizer Inc


Mylan N. V


Bristol-Myers Squibb Company


Eisai Co., Ltd


Zydus Cadila


Teva Pharmaceutical Industries Ltd


Aurobindo Pharma


Dr. Reddy’s Laboratories Ltd


Fresenius Kabi AG


Hikma Pharmaceuticals PLC


Novartis AG




Pressure Profile Systems


Endo Pharmaceuticals Inc


PAVmed Inc


Avadim Health, Inc



Recent Development

  • Sonex Health announced the commercial launch of their UltraGuideTFR gadget in the United States in April 2022. Using real-time ultrasound guidance, this device performs trigger finger release (TFR) procedures.
  • PAVmed Inc. stated in March 2022 that physicians at the Clinica Porto Azul in Barranquilla, Colombia, implanted the Company's PortIO Intraosseous Infusion System in three patients as part of a First-in-human clinical research with up to 40 patients approved by the IRB. 

Market Trend Analysis

"Advancing Wellness: Discovering New Trends in the Carpal Tunnel Syndrome Market."

The most frequently used techniques are open carpal tunnel releasing systems. These techniques are commonly used because they allow for accurate flexor retinaculum vision, direct visualization, and the identification of anatomical abnormalities. CTS is the most common compressive neuropathy, with a reported frequency of 3.8% in the general population, according to an NCBI paper published in June 2022. The benefits of single- or double-portal procedures are combined in mini-open carpal tunnel release (MCTR), which has been shown to have minimal rates of complications. In order to prevent these post-operative issues, open carpal tunnel release is the ideal method, which helps the segment under study expand.

A 2021 survey by the American Association for Hand Surgery revealed that 34% of participants preferred an endoscopic method, 46% preferred a mini-open incision, and 34% selected a regular open (extensile) incision. The expansion of this section of the market is thus anticipated to be driven by patients' desire for open carpal tunnel releasing methods. According to a June 2022 NCBI article, this procedure entails a risk of postoperative wound pain, scar sensibility, and pillar pain, despite its ability to provide direct vision, consistent flexor retinaculum separation, and the measurement of anatomical differences. Open carpal tunnel release (OCTR) is the most commonly used method, and this trend is predicted to increase demand for open carpal tunnel release system procedures.

As a result, elements including the increasing use of open carpal tunnel release devices and their effectiveness are anticipated to propel the segment's expansion throughout the projection period.

Clinical Trial Assessment

The DiseaseLandscape Insights consultancy firm provides valuable support in future market trends on the development of new pharmaceutical products. This support helps to streamline the planning and execution of clinical trials of novel medications and treatments, implement effective patient recruitment strategies, ensure regulatory compliance, and increase the likelihood of successful trial outcomes. 

The below table gives information about some currently ongoing clinical trials, including their study titles and respective stages:


Phase 1

Phase 2

Phase 3

Phase 4

Radiofrequency, Perineural Injection, Idiopathic Carpal Tunnel Syndrome

A Study of Fisetin to Treat Carpal Tunnel Syndrome

Ultrasound-guided Dextrose Injection Versus Dextrose with Methylprednisolone in Carpal Tunnel Syndrome

A Norwegian Trial Comparing Treatment Strategies for Carpal Tunnel Syndrome

Conditioning Electrical Stimulation to Improve Outcomes in Carpal Tunnel Syndrome

Botulinum Toxin Type A for Peripheral Neuropathic Pain in subjects With Carpal Tunnel Syndrome

The Stoical Study - The Soft Tissue Injection of Corticosteroid and Local Anesthetic Study

Local Injection of Steroid VS. Glucose 5% in Carpal Tunnel Syndrome


Conditioning Electrical Stimulation to Improve Outcomes in Carpal Tunnel Syndrome


Exparel and Education to Avoid Opioids After Carpal Tunnel Release



DiseaseLandscape Insights (DLI), a healthcare consulting firm, is prepared to provide a comprehensive range of strategic services to all our stakeholders in order to assist healthcare organizations in managing Carpal Tunnel Syndrome. Numerous services are offered, such as market research and analysis to spot trends and possibilities.

In addition, DLI offers guidance to clients in order to maintain regulatory compliance in a number of areas, including creating innovative product development strategies, collaborating with significant stakeholders, and applying clinical expertise for evidence-based approaches.

By offering personalized advice, DLI services enable clients to make informed decisions that enhance patient outcomes by guiding them through the complicated world of CTS management.

DLI's services make it easier for industry participants to conduct clinical studies for new drugs and treatments. It also facilitates other tasks like patient recruiting and regulatory compliance. DLI also gives industry participants comprehensive information about global regulations and guidelines, market trends, and rivals in the industry.

Vishal SawantBusiness Development

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