Anemia Disease

Gain Comprehensive Insights into Anemia Disease with DiseaseLandscape Insights

Understanding, Managing, and Coping with Anemia

Certain diseases have a significant impact on the health and well-being of people around the world, given the wide healthcare environment. A serious blood disease called anemia poses a quiet threat to countless individuals across the globe and presents difficulties for businesses and healthcare providers. This disease affects up to one-third of the global population.

In many cases, anemia is mild and asymptomatic among patients and therefore requires no management but some severe cases need to be treated immediately. But despite these challenges in the management of anemia, there are unrealized opportunities for development and innovation for healthcare marketers to focus on innovative diagnostics, therapies, and personalized treatments as they are pivotal in addressing the diverse and widespread impact of these diseases on individuals and healthcare systems globally.

Anemia is a worldwide public health concern, as it majorly affects young children, pregnant women, and menstruating girls and women. Globally, it is estimated that 40% of all children, and 37% of pregnant women, and Anaemia is estimated to affect half a billion women 30-50% of 15–49 years of age worldwide. According to the National Heart, Lung, and Blood Institute, anemia is considered to be the most common blood disorder, as it affects more than 3 million people globally.

Anemia is a severe condition among patients in which the number of red blood cells or the hemoglobin (Hb) concentration within them is lower than normal. Anemia occurs when there isn’t enough hemoglobin in the body to carry oxygen to the organs and tissues. In severe cases, anemia leads to poor cognitive and motor development in children. In many cases, it is mild and asymptomatic and requires no management.

The prevalence of the disease increases with age and is found to be more common in women of reproductive age, pregnant women, and the elderly. The prevalence is more than 20% of individuals who are older than the age of 85. The incidence of anemia is 50%-60% in the nursing population according to the nursing population. In the elderly, the cases have approximately one-third of patients have nutritional deficiency as the cause of different types of anemia, such as folate, and vitamin B12 deficiency. Almost one- third of patients have signs of chronic inflammation or renal failure.

Classically, mild iron deficiency anemia is seen in women of childbearing age, usually due to poor dietary intake of iron and monthly loss of menstrual cycles. Elderly people frequently develop anemia as a result of insufficient dietary habits, particularly for deficiencies of iron and folic acid.

Apart from age and sex, race is also an important determinant of anemia, with the prevalence increasing in the African and Southeast populations.  According to WHO Regions of Africa and South-East Asia are the most affected with an estimated 106 million women and 103 million children affected by anemia in Africa approximately 244 million women and 83 million children have been affected in South-East Asia

As per NIH, the reduction of anemia is a key priority of the World Health Assembly, as it targets Global Nutrition by 2025 and Sustainable Health Development Goals. Studies have proved that adequate dietary iron intake significantly prevents and treats IDA, which has brought a focus of market players on expanding product portfolios by the most cost-effective strategy to prevent, manage, and reduce anemia. 

Therefore, Market players are recognizing the significance of anemia disease management beyond treatment provision. With a shift towards holistic care, companies are embracing patient-centric approaches that encompass early diagnosis, personalized interventions, and patient education. This transition signifies a commitment to improve patient outcomes by addressing all the factors contributing to anemia, ultimately reshaping the landscape of anemia management.

Thereby, DiseaseLandscape Insights DLI is set to offer unparalleled solutions to all market players by delving deep into the complex landscape of healthcare trends. With extensive research and analytical expertise, DLI dissects evolving market dynamics, providing actionable insights to market players in shaping the diagnostic and treatment industry of anemia.

Diagnostic Analysis-

From Signs to Treatment: Understanding Anemia Diagnostics Types and Method

Diagnosing anemia involves a combination of medical history evaluation, physical examination, and specific diagnostic blood tests.  Anemia is generally diagnosed by measuring blood Hb concentration in patients. However, anemia can also be assessed using hematocrit and with more causal specificity through RBC parameters, such as mean cell volume mean cell Hb concentration, and reticulocyte count.

Accurate, precise, acceptable, and affordable tools for diagnosing anemia and its main determinants are essential for understanding the problem and the appropriate interventions needed for prevention and treatment. Some of the common diagnostics of laboratory testing imaging tests and genetic testing used to identify and classify anemia include:

1. Laboratory Testing

• Complete Blood Count (CBC):

  This is one of the primary tests used to diagnose anemia. It provides information about the number of red blood cells, white blood cells, and platelets, as well as the concentration of hemoglobin and hematocrit (the percentage of blood volume occupied by red blood cells). The CBC helps determine the type and severity of anemia

• Reticulocyte Count:

  Reticulocytes are immature red blood cells. Measuring the percentage of reticulocytes in the blood provides information about the bone marrow's ability to produce new red blood cells. Low reticulocyte counts indicate decreased red blood cell production

• Peripheral Blood Smear:

  In order to determine the size, shape, and appearance of red blood cells, a peripheral blood smear involves evaluating a sample of blood under a microscope. This helps to identify abnormalities such as variations in size (anisocytosis) and shape (poikilocytosis) of red blood cells, which provides clues about the underlying cause of anemia

• Thyroid Function Tests:

  This test is done to check the level of thyroxine (T4) and thyroid-stimulating hormone level (TSH). This test also includes measuring Activated Partial Thromboplastin Time (APTT), Prothrombin Time/International Normalized Ratio (PT/INR), and Thrombin Time (TT) which helps to understand the level of severity among the patients

• Serum Ferritin Level:

  Ferritin is a protein that stores iron. A low serum ferritin level indicates iron deficiency anemia, which is one of the most common types of anemia. Ferritin levels are used to assess iron stores in the body.

• Serum Iron and Total Iron-Binding Capacity (TIBC):

  These tests help evaluate iron levels and the body's ability to transport iron. Low serum iron levels and high TIBC levels are indicative of iron deficiency anemia.

2. Imaging Equipment -

   In some cases, imaging equipment is used to identify underlying causes of anemia. Here are some types of imaging equipment that might be used in specific situations related to anemia diagnosis.

• Endoscopy:

  Endoscopy involves using a flexible tube with a light and camera (endoscope) to visualize the inside of organs like the gastrointestinal tract. It is used to identify sources of bleeding, which leads to anemia. Types of endoscopies include upper gastrointestinal endoscopy (esophagogastroduodenoscopy) and colonoscopy.

• Ultrasound:

  Ultrasound imaging uses sound waves to create images of internal structures. While not typically used to diagnose anemia directly, ultrasound helps identify underlying conditions causing anemia, such as an enlarged spleen or liver, which might be affecting red blood cell health.

• MRI (Magnetic Resonance Imaging):

  MRI is a powerful imaging technique that uses strong magnetic fields and radio waves to create detailed images of the body's internal structures. In certain cases, MRI is used to evaluate bone marrow health and rule out bone marrow disorders as a cause of anemia.

• CT (Computed Tomography) Scan:

  CT scan combines X-ray and computer technology to create cross-sectional images of the body. It is used to identify sources of bleeding or to assess organ health that might be related to anemia causes.

• Nuclear Medicine Scans:

  These scans involve injecting a small amount of radioactive material into the body and using specialized cameras to capture images of how the material is absorbed. In some cases, nuclear medicine scans help diagnose certain blood disorders.

3. Genetic Testing Kit-

   This testing plays a crucial role in diagnosing hereditary forms of anemia, which are caused by specific genetic mutations that affect red blood cell production or function. There are different tests such as Ambry Genetics, Centogene, and Blueprint Genetics to identify the anemia disease.

• Ambry:

  Ambry Genetics provides genetic testing services for various hereditary disorders, including anemias. They offer panels that focus on specific types of anemias caused by genetic mutations.

• Centogene:

  Centogene specializes in genetic diagnostics for rare diseases. They might offer genetic testing for specific anemias with known genetic causes.

• Blueprint Genetics:

  Blueprint Genetics offers genetic testing for a wide range of inherited disorders, including certain anemias. They provide comprehensive panels that include genes associated with anemias.

The market leader receives assistance from DiseaseLandscape Insights in the creation of various diagnostic kits, the application of cutting-edge technology to enhance the present diagnostic approach, and the provision of information on current market participants and their offerings for a better understanding of market dynamics. Stakeholders decide the course of their businesses and put strategies in place for market expansion by using the services of DLI.

The following table lists the names of the market leaders who are reshaping healthcare with their forefront diagnostic innovations in the diagnosis of anemia:

Treatment Analysis-

Empowering Recovery from Anemia with Emerging Treatment Options for a Healthy Life

Treatment depends on the root cause that led to anemia. Treatment for the underlying disease frequently cures anemia and all of its symptoms. The different causes of anemia with their different methods of treatment -

1. Iron deficiency anemia:

    Changing one's diet and taking iron supplements are the typical treatments for this type of anemia. If blood loss is the cause of iron deficiency, controlling the bleeding and finding all the right sources is necessary to prevent anemia. This problem might involve surgery as treatment.

2. Vitamin deficiency anemia’s:

    Vitamin B-12 and folic acid deficiencies are effectively treated with dietary supplements and diet changes that include more of these nutrients. B-12 shots might be necessary for people who have problems absorbing the vitamin from food. The shots are initially given every other day. In due course, injections will only need to be administered once a month, maybe for life.

3. Haemolytic anemias:

    Haemolytic anemias include stopping medicines that might be causing them and treating infections. If the immune system is attacking red blood cells, treatment might involve taking medicines that lower immune system activity.

4. Sickle cell anemia:

    For pain relief and to avoid complications, a treatment plan may involve oxygen, painkillers, and intravenous hydration with fluids. It might involve getting a blood transfusion, taking folic acid supplements, and using some antibiotics.

 Additionally, a cancer drug called Hydroxyurea (Droxia, Hydrea, Siklos) also is used to treat sickle cell anemia.

5. Anemia of Chronic Disease:

    The illness that triggers this particular type of anemia is the primary aim of healthcare for treating such a disease. If symptoms worsen, in this type of chronic anemia, treatment options include blood transfusions or injections of the hormone erythropoietin.

The various chronic disorders are treated with medication, chemotherapy, or a transplant, which involves receiving bone marrow from a donor. Anemia caused by cancer or chronic renal disease requires special or additional care.

• Blood transfusion: Providers majorly use blood transfusions as a short-term alternative therapy to help patients who have severe anemia. Blood transfusions aren’t a long-term solution, as they have side effects that include iron overload and risk of infection and are sometimes fatal.
• Synthetic EPO therapy: EPO is a hormone in a patient’s body that kidneys make to help the bone marrow make red blood cells. This type of treatment is used in pregnant women to cure the imbalance of hormones.
• Iron supplements: Sometimes healthcare providers also combine EPO therapy and iron supplement therapy to overcome anemia.

6. Bone Marrow Transplant-

   It is a procedure that infuses healthy blood-forming stem cells into your body to replace bone marrow that's not producing enough healthy blood cells. A stem cell transplant is an alternative to a bone marrow transplant. Individuals might need a bone marrow transplant if their bone marrow stops working and does not produce enough healthy blood cells.

Bone marrow transplants use cells from your own body (autologous transplant) or from a donor (allogeneic transplant).

          Types of Bone Marrow Transplant-

• Autologous Transplant- Typically used in people who need to undergo high doses of chemotherapy and radiation to cure their diseases. The bone marrow is likely to be impacted by these therapies. Bone marrow that has been adversely affected in the patient's body is replaced with an autologous stem cell transplant. This transplant is most often used to treat diseases like Myeloma Plasma cell disorders.
• Allogeneic Transplant - A transplant is an option for people with a variety of cancerous and noncancerous diseases, including adrenoleukodystrophy, Chronic Leukaemia, Hodgkin's lymphoma Immune deficiencies, Multiple myeloma, and many more.

Market Trends Analysis-

Innovations in Anemia: Where Science and Compassion Collide

Market trends in the anemia disease industry have undergone significant changes and dynamic transformations in recent years. The increased emphasis on individualized and targeted treatment options has become a significant trend. Healthcare professionals are able to more accurately identify the root causes of anemia in specific patients, which enables them to develop more individualized treatment plans.

As per the National Institute of Health, iron deficiency anemia is one of the main nutritional deficiency disorders affecting large fractions of the population, In order to successfully treat particular types of anemia, increasing awareness of anemia and its treatments is leading to early diagnosis and treatment thereby has increased the adoption of cutting-edge drugs, such as novel medications, Iron supplements, and gene-based interventions.

Iron supplements, vitamin supplements such as Folic acid and Vitamin B12 are widely used to treat iron-deficiency anemia and vitamin deficiencies. This has increased demand for these supplements and is driving the growth of the anemia drugs market.

Furthermore, the market has witnessed a heightened focus on patient-centric care and improved quality of life. Stakeholders across the healthcare spectrum are recognizing the importance of not only managing anemia itself but also addressing the associated symptoms and complications that significantly impact patients' well-being. As a result, holistic approaches that incorporate nutritional support, lifestyle modifications, and psychological well-being interventions are gaining traction.

Additionally, the increasing prevalence of chronic kidney disease (CKD), Inflammatory Bowel Disease (IBD), and cancer globally has increased the need for iron medication treatment of subsequent iron deficiency anemia (IDA), along with the increasing geriatric population around the globe is propelling the market demand for drugs for anemia treatment.

Overall, the anemia disease market is undergoing a transformative phase, characterized by personalized treatments and a comprehensive approach to patient care, ultimately striving to enhance outcomes and elevate the quality of life for individuals living with anemia.

DiseaseLandscape Insight (DLI) supports market players with a data-driven approach and empowers clients with a comprehensive understanding of market trends, enabling companies to make informed strategic decisions.

By decoding shifts in demand, technology, and regulations, DLI navigates changes effectively and capitalizes on emerging opportunities for market players in the healthcare market, ensuring that clients stay ahead in an ever-changing environment.

Regulatory Framework Analysis-

Regulating Excellence in Anemia Management: Providing Better Health:

The regulatory framework governing the anemia disease market is a critical factor in ensuring patient safety, treatment efficacy, and market integrity. Regulatory agencies, such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), have set rigorous standards for the approval of anemia-related drugs, therapies, and medical devices.

Additionally, regulatory bodies have provided guidelines for accurate diagnosis, proper labeling, and clear communication of potential risks and benefits to both healthcare providers and patients. Following are some major approvals from regulatory authorities to cure and treat anemia disease

• In November 2022: Sanofi received approval from the European Commission (EC) for Enjaymo (sutimlimab) for the treatment of hemolytic anemia in adult patients with Cold Agglutinin Disease (CAD), which is a rare, severe, and chronic hemolytic anemia, where the patient’s body’s immune system, unfortunately, attacks healthy red blood cells and causes their rupture, known as hemolysis.
• CSL Vifor and Fresenius Kabi received approval in 2022 from China’s National NMPA for its Ferinject (Ferric Carboxymaltose), a preparation for intravenous iron therapy to treat iron deficiency in adult patients, especially for those patients who cannot take oral iron preparations are for those patients who do not show effective results after consuming oral preparations.
• Zydus' New Drug Application (NDA) for Oxemia was approved in 2022 by the Drug Controller General of India. In order to treat anemia associated with chronic kidney disease (CKD), oxyemia, an oral small-molecule inhibitor of hypoxia-inducible factor-prolyl hydroxylase (HIF-PH), is utilized.
• The first generic high-dose intravenous iron product, Ferumoxytol Injection, was set to go on sale in 2021, according to Sandoz. In American patients, this medicine is used to treat anemia brought on by iron deficiency. Ferumoxytol, a generic form of Feraheme from AMAG Pharmaceuticals, is used to treat IDA in adults who have an allergy to oral iron, a poor reaction to oral iron, or chronic renal illness.

Competitive Analysis –

The competitive landscape of the anemia disease market reflects a dynamic interplay of pharmaceutical companies, medical device manufacturers, and diagnostic providers. Major players in the industry are keenly focused on research and development efforts to introduce advanced therapeutic options with improved efficacy and fewer side effects. This drive has led to the emergence of novel drug formulations, including erythropoiesis-stimulating agents and iron replacement therapies, each competing for prominence in the market.

In addition to pharmaceutical innovations, diagnostic companies are playing a pivotal role in the market by developing sophisticated tests that aid in precise anemia diagnosis and classification. Furthermore, partnerships and collaborations between pharmaceutical firms, diagnostic companies, and research institutions are shaping the landscape, as they facilitate knowledge exchange, streamlined development processes, and a broader reach into global markets. As the market continues to evolve, the competition is expected to remain intense and competitive.

Here are some Notable deals among the major companies towards effective therapies and comprehensive diagnostic tools for anemia management -

• Pfizer and BioNTech announced a partnership in 2021 to create and market a potential treatment for Sickle Cell Disease and Beta-Thalassemia, two types of hemoglobin abnormalities that can cause anemia.
• In 2020, Global Blood Therapeutics (GBT) Partnership with Syros Pharmaceuticals GBT and Syros entered into a collaboration to develop novel therapies for sickle cell disease, a type of anemia.
• Bristol Myers Squibb (BMS) Acquires Celgene: In 2019, BMS completed the acquisition of Celgene, a company that is involved in the development of treatments for anemia, including drugs like Epoetin Alfa.
• Acceleron Pharma and Bristol Myers Squibb Partnership: These companies collaborated on the development of luspatercept, a drug aimed at treating anemia associated with myelodysplastic syndromes and beta-thalassemia.

Clinical Trial Analysis-

The importance of clinical trials in the field of evidence-based medicine and healthcare transition has been highlighted by the government's growing emphasis on comparative effectiveness studies. One of the main goals of the healthcare revolution is achieved with the assistance of clinical data, which allows market participants to accurately compare medical therapy.

The table below highlights the study titles of the ongoing clinical trials as well as the stages in which they are taking place.

Conclusion-

For healthcare organizations looking to effectively manage anemia, DiseaseLandscape Insights (DLI) a healthcare consulting firm is ready to offer a wide range of strategic services to all our stakeholders. Services with a wide range that includes conducting market research and analysis to identify trends and opportunities.

Additionally, DLI also provides advice to clients in order to ensure regulatory compliance on utilizing clinical expertise for evidence-based approaches, developing creative product development strategies, facilitating collaboration with important stakeholders, and more.

DLI services are equipped to navigate clients on the complex landscape of anemia management and help them make well-informed choices that improve patient outcomes by providing customized recommendations.