Deep Vein Thrombosis Disease

Published Date : Jan 2024
Category : Cardiovascular Diseases
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"Navigating the Waves: The Unveiling Market Insights and Trends in Deep Vein Thrombosis with Disease Landscape Insights"

Deep vein thrombosis (DVT) is a major global health concern that affects millions of people annually. Healthcare practitioners, researchers, and industry players must comprehend the market scenario as the prevalence of this vascular condition rises.

According to NIH, deep vein thrombosis are frequent, "silent" conditions that are missed or discovered only after an autopsy. As a result, it is common to underestimate the incidence and prevalence. Lower limb DVT is thought to occur in one instance out of every 1000 people, with an annual incidence of 80 cases per 100,000 people. More than 200,000 Americans get venous thrombosis each year, and 50,000 of those instances are worsened by pulmonary embolism. Research from the United States indicates that African Americans and Whites have a higher incidence of DVT and a higher risk of complications than Hispanics and Asians.

Venous reflux is hampered by the obstructive conditions known as deep vein thrombosis (DVT). The upper limb venous system is typically affected by DVT, as clots develop in deep calf veins and spread proximally. It is a common venous thromboembolic (VTE) condition, occurring one in every 1000 years. Distal veins account for 40% of the rate of involvement, popliteal veins for 16%, femoral veins for 20%, common femoral veins for 20%, and iliac veins for 4%, depending on the anatomical location.

A blood clot known as a deep-vein thrombosis (DVT) develops in the deep veins, commonly in the legs, but it can also happen in the arms, mesenteric, and cerebral veins.

Deep vein thrombosis is a prevalent and significant illness. After heart attacks and strokes, it is the third most prevalent cause of death from cardiovascular illness and falls under the category of venous thromboembolism disorders. Major causes of morbidity, even in patients without pulmonary emboli, include "post-thrombotic syndrome" and recurrent thrombosis.

Most pulmonary embolism instances are caused by a serious medical condition called deep-vein thrombosis. Reducing morbidity requires early diagnosis and treatment.


Several factors that impact deep vein blood flow and raise the possibility of blood clot development. Among them are:

  • Growing older
  • History of pulmonary embolism or DVT in oneself or one's family
  • Being afflicted by cancer
  • Having venous conditions, such varicose veins
  • Smoking Hormone treatment or birth control medications Pregnancy
  • Obese or overweight
  • Getting a blood-clotting condition from birth

Normal blood flow and clotting is disrupted by a fractured hip or leg, severe surgery on the hip, knee, or lower leg, or both. Blood clots in veins in orthopedic cases are mostly caused by three factors: impaired veins, poor blood flow, and hypercoagulation.

The risk factors that are thought to be the root causes of DVT include cancer, some autoimmune diseases, including lupus, smoking cigarettes, situations that increase the risk of blood clot development, using birth control tablets or estrogens (smoking increases this risk even further). When traveling, extended periods of sitting raise the risk of DVT. This is more likely to occur if you also possess one or more of the previously mentioned risk factors.

Sign & Symptoms

Approximately fifty percent of people with DVT never have any symptoms at all. Leg soreness and calf muscle tenderness are the most typical symptoms. Additionally, one leg may appear swollen or turn blue or purple in color. These indicators. These symptoms could emerge quickly or gradually over a brief period. Among the signs and symptoms of a DVT are:

  • Skin redness
  • Warm-feeling skin when touched.
  • Edema, or swelling, in the arm or leg.
  • Soreness & pain in the arm or leg

Diagnostic Analysis

Imaging Test

  • Duplex Ultrasound

For DVT, duplex ultrasound is the most often used test. High-frequency sound waves are employed in ultrasounds, and they reverberate off the body, much as the technology used to monitor fetal health. This makes the blood vessels seem like a picture. By combining Doppler technology with conventional ultrasound technology, duplex ultrasound creates a color image that depicts blood flowing through the body.

Ultrasound is a painless and noninvasive technology. Since it doesn't involve radiation, it can be done often. When a blood clot is not the cause of your symptoms, duplex ultrasonography assists identify alternative explanations.

  • Magnetic Resonance Imaging (MRI)

An MRI creates finely detailed, cross-sectional pictures of internal body systems, such as veins and blood vessels. The examination is noninvasive and painless. An MRI is a rare but useful tool used by some clinicians to find blood clots in the thigh and pelvis. With MRI, both legs can be seen simultaneously. On the other hand, individuals who have pacemakers or other implanted devices use it.

  • Venography

This test makes an image of the legs and feet's veins using dye and X-rays. A sizable vein in the foot or ankle is used to receive the dye injection. It enhances the visibility of blood vessels on X-rays. The test is rarely performed because it is intrusive. Other examinations, such ultrasounds, are frequent.

  • Computed Tomography (CT) Scan

Using a computed tomography (CT) scan, gives internal body structures. A CT scan is used by doctors to detect blood clots in the lungs (pulmonary embolism) and DVT in the abdomen, pelvis, or brain.

D-Dimer Blood Test

 One type of protein that blood clots manufacture is called D dimer. D dimer levels are elevated in nearly all cases of severe DVT. Frequently, this test aids in ruling out pulmonary embolism (PE).

Diagnostic Market Players:

Diagnostic Market Players

Diagnostic Product

GE Healthcare

Optima™ CT

Siemens Healthineers


Thermo Fisher Scientific


Canon Medical Systems

Discovery™ CT

Philips Healthcare


Shimadzu Corporation

SIGNA™ Pioneer

Ganesh Diagnostic & Imaging Centre Pvt. Ltd.

Revolution™ CT

Chakra Biomed Private Limited

Discovery™ PET/CT

AdvaCare Pharma

Discovery™ MI

Getein Biotech, Inc.




CTK Biotech, Inc.







Treatment Analysis

The goals of DVT treatment are to lower morbidity, avoid or reduce the risk of pulmonary embolism, and prevent or minimize the development of post-thrombotic syndrome.

Anticoagulation is the mainstay of treatment. According to NICE guidelines, only patients with pulmonary emboli and proximal DVT—not distal DVT—should be treated. The advantages and disadvantages of anticoagulation must be considered for each patient. Treatment for DVT lasts three to six months, although it may take up to twelve months if the condition recurs. Cancer patients require ongoing care.

The primary approach to treating DVT should be based on the underlying cause of the condition, which is as follows:


Anticoagulant: These medications lessen the blood's capacity to clot. Anticoagulants include heparin and warfarin, for instance. Additional anticoagulants, such as enoxaparin, dabigatran, apixaban, and rivaroxaban, are also utilized. Bleeding is the most common adverse consequence of blood thinners.

Thrombolytic agents: The doctor advises utilizing thrombolytics in specific situations. These clot-dissolving drugs are only used in cases when there is an exceedingly high danger of pulmonary embolism. They are injected directly into the blood clot via a catheter.

Surgical Measures

Vena Cava Filter:  If anticoagulants fail to prevent the growth of a blood clot, or if have a medical condition that makes it impossible to take anticoagulation drugs, doctor advises surgery to place a small device called a vena cava filter into the major vein that supplies heart. Most blood clots that are going through the bloodstream will be caught by this filter before they enter the lungs and result in a PE or DVT.

Compression Devices

After surgery, intermittent pneumatic compression devices guard against dangerous blood clots. These gadgets are used by people who are unable to walk to maintain blood flow in their legs. These gadgets serve as a substitute for blood thinners.

In addition, compression stockings made of graded elastic are tight at the ankle and loose as they rise the leg. Because of the compression they produce, blood does not pool in the veins, which may improve circulation.

Treatment Market Players:

                                                                   Treatment Market Players


Surgeries & Devices

Aspen Holdings

Boston Scientific Corporation

Glenmark Pharmaceuticals Inc

Cardinal Health

Bristol-Myers Squibb Company

Terumo Europe NV

Daiichi Sankyo Company, Limited

Canon Medical Systems

Johnson & Johnson Services, Inc.

Samsung Healthcare

Tianyu Pharmaceutical Co., Ltd.

Siemens Healthcare Private Limited

Neuland Laboratories Ltd


BoehringerIngelheim GmbH

Zimmer Biomet

Bayer AG

Mego Afek AC LTD


ThermoTek USA


Medline Industries, LP


B. Braun Interventional Systems, Inc.

Below tables provide insights regarding the diverse manufacturers and their products which are paving the way for effective treatment of the disease.

                                                            Treatment Products




ALN Optional Filter


ALN Optional Filter with Hook


VenaTech Convertible Filter


VenaTech LP Filter




Günther Tulip Filter





Trend Analysis

Over the past few years, there has been a notable increase in the worldwide market for deep vein thrombosis (DVT). The pharmaceutical and healthcare industries are changing quickly due to technological advancements, rising healthcare costs, and bettering healthcare infrastructure and procedures. Around the world, many clinics, hospitals, and ambulatory surgical care facilities are implementing cutting-edge machinery and gadgets. Deep vein thrombosis (DVT) revenue growth is largely driven by factors like rising chronic disease prevalence, quick medical and healthcare advancements, widespread use of the newest tools and techniques, and expanding funding from both public and private sources. Furthermore, there is a growing emphasis on medication development, a growing need for precision medicine, a high uptake of home care settings and point-of-care diagnostics, and a rise in funding for research and development.

Regulatory Framework

Guidelines for precise diagnosis, appropriate labeling, and transparent disclosure of potential hazards and benefits to patients and healthcare professionals have been offered by regulatory authorities. The regulatory bodies that have granted key approvals to treat and cure DVT conditions are given below.

15 November 2023, TGA has approved Heparin INTERPHARMA of Interpharma Pty Ltd. Heparin Interpharma (heparin sodium) was approved for the therapeutic use in Prophylaxis and treatment of deep vein thrombosis for use in patients 18 years and older.

Furthermore, TGA has given approval and registered various generic medicines for treatment of Deep Vein Thrombosis in 2023. Some of the registered generic drugs are listed below:

  • The new generic medication RIVALEM from Alembic Pharmaceuticals Australia Pty Ltd was registered by the TGA on October 3, 2023. For adult patients who have had major lower limb orthopaedic surgery (elective total hip replacement, treatment for up to 5 weeks; elective complete knee replacement, treatment for up to 2 weeks), Rivalem is recommended as a preventive measure against venous thromboembolism (VTE).
  • Cipla Australia Pty Ltd's CIP RIVAROXABAN will be available on February 6, 2023, for the treatment of pulmonary embolism (PE) and deep vein thrombosis (DVT), as well as the prevention of recurrent PE and DVT.
  • On June 13, 2023, RIVATOR of Torrent Australasia Pty Ltd was registered to treat deep vein thrombosis (DVT).

Clinical Trail Assessment

The importance of clinical trials in the field of evidence-based medicine and healthcare evolution has been highlighted by the government's spreading emphasis on relative effectiveness studies. One of the main goals of the healthcare revolution is achieved with the assistance of clinical data, which allows market participants to compare medical therapies accurately.

The table below highlights the study titles of the ongoing clinical trials as well as the stages in which they are taking place.

Phase 1

Phase 2

Phase 3

phase 4

Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis

Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis

Prophylactic vs Therapeutic Anticoagulation in Symptomatic Isolated Distal Deep Vein Thrombosis

Study Evaluation of Recombinant Hirudin in Prophylaxis of Post-Operative Deep Vein Thrombosis

PET Fibrin Imaging of DVT and PE

Diagnostic Validity of [18F]GP1 PET for Diagnosing Acute Deep Vein Thrombosis

Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients with Left Iliac Vein Compression - The PLICTS Study

The Danish Non-Vitamin K Antagonist Oral Anticoagulation Study in Patients with Venous Thromboembolism (DANNOAC-VTE)


Catheter-Related Early Thromboprophylaxis with Enoxaparin Studies

Catheter-Related Early Thromboprophylaxis with Enoxaparin Studies

Pre-operative Enoxaparin in the Surgical Management of Multi-trauma Patients Undergoing Orthopedic Surgical Procedures


A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants

A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE

A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery



DiseaseLandscape Insights (DLI) helps the industry by expediting patient recruitment, clinical trial protocols, and regulatory compliance for new medicines. DLI contributes to the objective of the healthcare industry of developing breakthrough technologies that radiate commercial potential in the portfolio of DVT therapies.

DLI services intend to assess the burden caused by the DVT condition by considering a variety of factors that suggest future market trends for pharmaceutical companies conducting research & development for DVT diagnostic tools and medications. DiseaseLandscape Insight disseminates market analysis and business insights developed by highly trained and informed industry analysts.

Vishal SawantBusiness Development

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