Posluma: A Cutting-Edge Advancement in Prostate Cancer Imaging by Targeted Oncology

Published Date : Jul 2023
Author : Pratibha Bhattacharjee
Biography : Sr. content writer at Brand Essence Market Research. Passionate about content curation in the market research vertical. Always striving to create reliable and engaging industry-based content.

In the relentless pursuit of groundbreaking advancements in oncology, Targeted Oncology has introduced Posluma, a transformative drug with the active ingredient flotufolastat F 18. This innovative medication marks a significant leap forward in the field of positron emission tomography (PET) imaging for patients with prostate cancer. Posluma offers new hope in detecting and managing this prevalent and complex malignancy.

Understanding Posluma

Posluma is a cutting-edge PET imaging agent that utilizes the active ingredient flotufolastat F 18. This novel radiotracer has been specially designed to target and bind to prostate-specific membrane antigen (PSMA), a protein that is overexpressed in prostate cancer cells. By utilizing Posluma during PET imaging, oncologists can gain valuable insights into the extent and localization of prostate cancer within the body, aiding in accurate diagnosis and personalized treatment planning.

Working of Posluma

Flotufolastat F 18, the core component of Posluma, is a small molecule that binds selectively to PSMA. PSMA is abundantly expressed on the surface of prostate cancer cells, including metastatic lesions. Once administered, Posluma is rapidly taken up by cancer cells expressing PSMA. The PET scanner detects the radioactive emissions from the flotufolastat F 18, generating detailed and high-resolution images that reveal the distribution of PSMA-positive tumor cells throughout the body.

Posluma’s Benefits

Early Detection: Prostate cancer can be challenging to detect, especially in its early stages when symptoms may be subtle or absent. Posluma's PSMA-targeted imaging enables more accurate detection and localization of tumors, even in cases where conventional imaging techniques may be inconclusive. Early detection is crucial for initiating timely treatment and improving patient outcomes.

Personalized Treatment Planning: Precise visualization of PSMA-expressing tumor cells helps oncologists tailor treatment plans to the specific characteristics of the cancer. This personalized approach can lead to more effective treatments, reduced side effects, and potentially improved patient survival rates.

Numerical Considerations

Prevalence of Prostate Cancer: Prostate cancer is one of the most common cancers in men worldwide, with an estimated 1.4 million new cases diagnosed each year. It is the second most commonly diagnosed cancer in men after skin cancer.

PSMA Expression in Prostate Cancer: Nearly all prostate cancers, including primary tumors and metastatic lesions, express PSMA to varying degrees. This makes PSMA an excellent target for imaging and therapeutic purposes.

Impact of PET Imaging: PET imaging is a valuable tool in cancer diagnosis and staging. In patients with prostate cancer, PET scans have shown higher sensitivity and specificity for detecting cancerous lesions compared to conventional imaging modalities.

How Posluma Will Help

Accurate Staging: Precise staging of prostate cancer is essential for determining the extent of the disease and selecting the most appropriate treatment strategy. Posluma's PSMA-targeted imaging aids in accurately staging prostate cancer, ensuring patients receive the most appropriate care for their specific disease stage. It can detect small metastatic lesions that may not be visible with other imaging methods, allowing for more accurate disease assessment.

Detection of Recurrence: Prostate cancer can recur or metastasize even after initial treatment. Posluma's ability to detect PSMA-positive tumor cells in distant sites enables early identification of recurrence, facilitating timely intervention and management. Early detection of recurrence allows for prompt treatment adjustments, potentially improving patient outcomes.

Monitoring Treatment Response: Posluma's PSMA-targeted PET imaging can also be used to monitor treatment response in patients undergoing prostate cancer therapy. By tracking changes in PSMA expression, oncologists can assess treatment efficacy and adjust therapies as needed. This real-time feedback allows for dynamic treatment modifications, ensuring patients receive the most effective therapies throughout their cancer journey.


Posluma, the revolutionary PET imaging agent by Targeted Oncology with flotufolastat F 18 as its active ingredient, represents a significant advancement in the field of prostate cancer detection and management. By targeting PSMA, Posluma offers accurate and personalized imaging, enabling precise staging, detection of recurrence, and monitoring of treatment response in patients affected by prostate cancer.

The introduction of Posluma into the diagnostic landscape holds the promise of transforming prostate cancer care, reaffirming Targeted Oncology's commitment to scientific innovation and patient-centric approaches. As Posluma continues to make its way through the regulatory process, it stands to revolutionize prostate cancer imaging, offering new hope, improved treatment outcomes, and a brighter future for patients worldwide.

With its potential to detect cancer at an early stage, accurately stage the disease, and monitor treatment response, Posluma has the potential to significantly impact the lives of individuals affected by prostate cancer. Now that Posluma has received its approval and as non-invasive and precise imaging tool, it will be a game-changer in the fight against prostate cancer, guiding treatment decisions and ultimately improving patient survival and quality of life.

Vishal SawantBusiness Development

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