Let's Beat the Challenge: Reach New Heights with Benzathine Penicillin G Mass Production

Published Date : Sep 2023
Author : Shruti Gaikwad


Let us take a step ahead to focus on the battle against Strep Throat-induced rheumatic fever and Benzathine Penicillin G, the most frequently prescribed antibiotic worldwide. As we know antibiotics have been praised for their capacity to change how symptoms are managed and provide a lifeline of stability to those who suffer from infections.

Introduction about Disease.

Among infections, Strep Throat is a widely spread bacterial infection caused by streptococcus bacteria which is a fatal invasive infection because of which it is becoming a major public health problem worldwide. When strep throat is not treated rheumatic fever inflammatory disease develops. Rheumatic fever causes damage to the heart and heart vessels. So, there is a need for proper treatment of this disease.

Every year, more than 616 million new cases of strep throat are seen by healthcare practitioners across the globe. A promising new FDA-approved therapeutic option and the most prevalent antibiotic used for strep throat fever is Benzathine Penicillin G a critical drug (BCG). It is an injectable antibiotic that maintains a high level of penicillin in the blood for an extended period and reduces bacterial inflammation.

Welcome to our blog post, in which we explore the complex process of making the antibiotic Benzathine Penicillin G (BCG). Market participants are facing numerous types of difficulties in their production and in the supply chain since the demand for this crucial antibiotic is rising steadily.

Join us as we explore these challenges as well as the exciting opportunities that lie ahead for market participants who are ready to effectively deal with the changing environment and make an impact that is involved in satisfying the rising demand for this unique drug, known for its potent ability to reduce bacterial inflammation.

“Unambiguous therapeutic need for BPG”

If we are talking about BPG we need to talk about factors affecting the BPG demand- which includes a lack of comparative effective antibiotics, global disease burden, the serious clinical effects of untreated illness, and the insufficient systems for providing the therapy. These factors lead to the increased demand for BPG in the market and after some level, it turns into scarcity.

Why is the world facing a Scarcity of BPG Antibiotics?

The number of strep throat patients is growing as time passes so; this demands a rise in an expansion of the production of BPG. However, manufacturers are facing many difficulties in the production of BPG which leads to the shortage of the drug. Industry players have the potential to transform the field of therapy. Let’s understand the reasons for the shortage of BPG production.

  • A major reason for the shortage of BPG is the scattered chaos of manufacturers, suppliers, and purchasing agencies. Increased cases of Strep Throat led to Rheumatic heart disease making it another reason for the shortage of BPG.
  • As a result, governments and buying agencies tried to obtain BPG at any cost and store them for future use, which turned into substantial global shortages.

Challenges for BPG Shortage

Now, let us understand the various risk factors as shown below that are responsible for the scarcity of BPG antibiotics.


API Quality -

Active Pharmaceutical Ingredient manufacturers of BPG like North China Pharmaceutical Group Semiyntech Co. Ltd were found to be non-compliant with the GMP. Due to this the quality of BPG is also decreasing and causes adverse reactions in patients. None of the current Active Pharmaceutical Ingredient manufacturers of BPG has market authorization from regulatory bodies. Maintaining quality and quantity is a major challenge for companies in the BPG shortage era.

Limited Shelf Life -

The time for which the BPG remains safe to eat is 14 days which is very less. As the supply chain is fragmented, 14 days are not enough to reach the BPG at the correct place and causes waste of the product.  Innovations in the replacement of some Active Pharmaceutical Ingredients to increase the shelf life is another major concern for manufacturers to deal with.

Off-Patent Drug –

As API manufacturers do not have market approval, the drug is sold as off off-patent drug in the market. Conducting pediatric clinical trials for off-patent drugs is difficult for industries due to regulatory rules and regulations. Therefore, it becomes challenging for stakeholders and firms to conduct trials for off-patent drugs and overcome the shortage of BPG antibiotics.

Low Selling Prize -

After facing such difficulties companies suffer from another challenge which is the selling price of BPG is low as per the guidelines for off-patent drugs. For the production of BPG, a huge amount of investment in instruments, other adjuvants costs, and infrastructure is required. A large investment with a small return is not a wise business practice. The primary challenge for market participants is the development of low-investment, high-return schemes.

After dealing with such challenges and investing an adequate amount of money and time, the selling price of BPG in the market is low, pulling the leg back of the industry players from entering the BPG landscape. But for every problem, there is a proper way to look into it. Stakeholders have various opportunities in the BPG field as well. 

BPG is a highly demanded antibiotic all over the world. So, why not enhance the BPG while also expanding the business?

The shortage of BPG has prompted experts to search for an innovative approach to expand the production of BPG. Improvement in BPG will improve patient health and the business of industry players. Below are some of the scope areas for market players in the field of large-scale production, supply, and demand of BPG-

  • Options for new product development or reformulation
  • Pain relief at the injection site
  • Longer-acting formulations
  • Regulatory issues and extending licensing to novel indications.

This blog indicates that mass manufacturing of BPG is a challenge, and opportunity for stakeholders in the BPG domain needs effort, and teamwork. Overcoming these hurdles by the companies shows the potential to change the landscape of strep throat-induced rheumatic fever, bringing in a new age of antibiotic therapy and, ultimately, a brighter future for those in need.


There are exciting new opportunities open for healthcare firms. The complete strategies of DiseaseLandscape Insights (DLI) assist all the market leaders in resolving the challenges of the shortage of BPG in the world. The DLI service also provides the knowledge of collaborations, research institutes, and other funding agencies for the improvement to increase the manufacturing rate of drugs.

DLI data empowers businesses to grasp the profound impact of BPG, fostering informed decisions and partnerships that drive innovation in the realm of strep throat care. A novel technique always promises a brighter future for people living with strep throat. So, let’s start the journey of creating a brighter future in which every improvement brings us one step closer to a world devoid of bacterial infectious diseases such as strep throat-induced rheumatic fever.

Vishal SawantBusiness Development

How we can help?

  • 1-888-853-7040 - U.S. (TOLL FREE)
  • +44-1173181773 - U.K. OFFICE
  • +91-7447409162 - INDIA OFFICE
1Chat With UsBook AppointmentBook 15 min Free Analyst Call
We are always looking to hire talented individuals with equal and extraordinary proportions of industry expertise, problem solving ability and inclination interested? please email us
  • FAQ
Disease Landscape Insights LLP
6th Floor, Sr No.207, Office A H 6070 Phase 1, Solitaire Business Hub, Viman Nagar, Pune, Maharashtra, 411014
1-888-853-7040 - U.S. (TOLL FREE)+44-1173181773 - U.K. OFFICE+91-7447409162 - INDIA OFFICE
© Copyright 2024-25 Disease Landscape Insights LLP. All Rights Reserved | Designed by Disease Landscape